A Brief Explanation
Cannabidiol (CBD) is a chemical in the Cannabis sativa plant, also known as cannabis or hemp. There are several therapeutic advantages of CBD, such as reducing pain and inflammation and mood-enhancing effects. However, the potential for CBD to improve moods is without the euphoric high associated with tetrahydrocannabinol (THC). Due to this, CBD oil, or CBD gummies in the U.K., can be a well-liked and safe natural treatment for mood disorders, including anxiety, depression, and others.
1. CBD: What Is It?
CBD is among 150 naturally occurring cannabinoids in cannabis, constituting up to 40% of the plant’s extract. Unlike THC, it lacks psychoactive effects, not causing the characteristic “high.”
The number of CBD oils and hemp extract products on the market has risen dramatically because people are experiencing improvements in their health and wellness after incorporating this health supplement into their regular dietary routine. Further, the best CBD oil products are thus made from whole hemp plant extract, containing a full spectrum of cannabinoids and other beneficial plant elements such as terpenes and flavonoids.
2. How Does CBD Work?
Understanding your endocannabinoid system (ECS) is key to comprehending CBD’s effects. The human body possesses a complex network called the ECS, comprising enzymes, lipids, and receptors. This system plays a vital role in maintaining body balance, or homeostasis.
The discovery of the endocannabinoid system in the 20th century revolutionized human health. CBD interacts with brain receptors, influencing the ECS, which regulates mood, immune response, appetite, and memory.
The ECS oversees numerous essential functions, including reproduction. It influences every aspect of life; finding a bodily process devoid of ECS involvement would be challenging.
What does this signify for people who use medical marijuana? Because of the ECS’s different receptors and how cannabis binds to them, medical marijuana may be used to treat various ailments. The endocannabinoid system is crucial in maintaining your health balance, from cancer to epilepsy.
Here are several possible mechanisms through which CBD interacts with various receptors and provides therapeutic benefits.
CBD And Epilepsy
Epidiolex’s Food and Drug Administration (FDA) approval for treating severe forms of epilepsy represents one of the biggest advances in cannabis medicine. The first cannabis drug not made synthetically to receive FDA approval is called Epidiolex. Such drugs help control and avert epileptic seizures. CBD can eliminate the adverse effects caused by certain anti-seizure medications. Additionally, it also improves the health and quality of life of epilepsy patients.
Mood Disorders And CBD
CBD has anxiolytic and depressive qualities with no or low adverse effects. As a result, CBD is a promising novel medication for treating anxiety and mood disorders. A 2014 animal study discovered that CBD’s action on these brain receptors caused antidepressant and anti-anxiety benefits. An assessment of current studies showed that CBD has anti-stress properties, which may alleviate stress-related depression.
Pain Receptors And CBD
According to research, CBD may be able to “desensitize” the TRPV1 receptor. The TRPV1 receptor, which also senses heat and discomfort, aids in controlling our body temperature. CBD’s analgesic (pain-killing), antiemetic (nausea-beating), and seizure-controlling qualities result from this interaction. Because CBD is an allosteric modulator, it may also have analgesic effects.
The Immune System And CBD
CB1 and CB2 receptors are crucial for immune system operation. Compared to CB2 receptors, which are often present in the peripheral nervous system, CB1 receptors are more prevalent in the central nervous system. CBD can inhibit the synthesis of cytokines, hence lowering immune response-related inflammation.
The Brain And CBD
An essential glutamate receptor for neuroplasticity and memory consolidation is the NMDA receptor. This endows CBD with neuroprotective qualities and may aid in regulating mental processes like memory formation, mood regulation, and learning. This interaction may also explain the anticonvulsant properties of CBD and its usage as an antipsychotic.
Liver And CBD
Cannabidiol can heal brain disease by restoring liver function, normalizing 5-HT levels, and normalizing brain function. As a result, cannabidiol’s effects may originate from a combination of its actions in the liver and brain. CBD possesses anti-inflammatory and antioxidant effects. It is, therefore, helpful in decreasing inflammatory responses and preserving the liver from oxidative damage. CBD substantially reduces inflammation and oxidative stress and eliminates malignant cells in experimental animals.
The Entourage Effect
The cannabinoids, flavonoids, terpenes, and fatty acids that are naturally present in hemp cause an effect known as the entourage effect. CBD may not be self-sufficient in treating all illnesses. But when combined with a bit of THC (even in non- or low-psychoactive quantities) and the plant’s terpenes, it has several beneficial purposes. However, many people turn to CBD to prevent getting high from THC. Pure CBD is the best option if your objective is to profit from cannabis without getting high.
CBD is a popular plant that holds many therapeutic benefits. However, you can feel the effects of CBD within 10-15 mins if you are using it sublingually, whereas edibles and topical takes more time to show their results. Lastly, a person needs to consult their doctor about using CBD in a treatment plan if the usage is for a medical condition.